Science, early intervention, and social action offer true hope for healing.
Nadine Burke Harris uses ACE research to show how child trauma changes brain, hormones, immune system, DNA, and behavior, and unlocks real models for prevention and healing.
What Are ACEs and Why Are They Crucial?
ACE includes abuse (physical, emotional, sexual), neglect, parental mental illness/drug abuse, divorce, domestic violence, incarceration. Chronic survival instinct threats reshape brain development, negative coping, disease risk.
The Science—Brain, Hormones, Immune System & DNA
Chronic stress alters brain structure (reward, fear, impulse), overdrives HPA axis, weakens immune response, and rewires DNA. Even routine stress triggers anxiety, autoimmune disease, chronic illness; MRIs show marked brain difference after trauma.
ACE Score & Lifelong Disease Risk
With ACE score 4+, adults see chronic lung disease/hepatitis risk 2.5x, depression risk 4.5x, suicide risk 12x, heart disease/cancer risk 3x, lifespan cut by 20 years.
Prevention, Healing, Diagnosis—What Works
SF Clinic (Burke Harris): ACE screening, team care (mental, nutrition, home visits), focused intervention for 4+ ACEs, long-term family/school/community support—demonstrated positive life changes.
Social/Policy Action
- Nationwide ACE screening
- Integrated mental/physical/social care networks
- Early detection, preventive education, societal awareness
- Family, school, health professionals, and policy coalitions
Q&A: Common Questions
Conclusion—The Path Forward
“Admitting the problem and acting as a community build a future of healing and prevention.”
